Log in to save to my catalogue

Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not...

Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2227830742

Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38

About this item

Full title

Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38

Publisher

United States: Public Library of Science

Journal title

PloS one, 2019-05, Vol.14 (5), p.e0216668-e0216668

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Oxidative stress has been shown to play a crucial role in the pathophysiology of the neurodegenerative disease Ataxia Telangiectasia. We have recently demonstrated that Dexamethasone treatment is able to counteract the oxidative state by promoting nuclear factor erythroid 2-related factor 2 (NRF2) nuclear accumulation. However, substantial gaps rem...

Alternative Titles

Full title

Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2227830742

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2227830742

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0216668

How to access this item