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EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hyperm...

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hyperm...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251134112

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

About this item

Full title

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2019-01, Vol.15 (1), p.e1007514-e1007514

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras association domain family isoform 1A (RASSF1A) is a cellular tumor suppressor, which regulates a broad range of cel...

Alternative Titles

Full title

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2251134112

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251134112

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1007514

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