EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hyperm...
EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras association domain family isoform 1A (RASSF1A) is a cellular tumor suppressor, which regulates a broad range of cel...
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Full title
EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation
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TN_cdi_plos_journals_2251134112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251134112
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1007514
