Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial...
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
About this item
Full title
Author / Creator
von Geldern, Thomas W. , Morton, Howard E. , Clark, Rick F. , Brown, Brian S. , Johnston, Kelly L. , Ford, Louise , Specht, Sabine , Carr, Robert A. , Stolarik, Deanne F. , Ma, Junli , Rieser, Matthew J. , Struever, Dominique , Frohberger, Stefan J. , Koschel, Marianne , Ehrens, Alexandra , Turner, Joseph D. , Hübner, Marc P. , Hoerauf, Achim , Taylor, Mark J. , Ward, Stephen A. , Marsh, Kennan and Kempf, Dale J.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administration (MDA) with current microfilaricides, and to pr...
Alternative Titles
Full title
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
Authors, Artists and Contributors
Author / Creator
Morton, Howard E.
Clark, Rick F.
Brown, Brian S.
Johnston, Kelly L.
Ford, Louise
Specht, Sabine
Carr, Robert A.
Stolarik, Deanne F.
Ma, Junli
Rieser, Matthew J.
Struever, Dominique
Frohberger, Stefan J.
Koschel, Marianne
Ehrens, Alexandra
Turner, Joseph D.
Hübner, Marc P.
Hoerauf, Achim
Taylor, Mark J.
Ward, Stephen A.
Marsh, Kennan
Kempf, Dale J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2252311050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2252311050
Other Identifiers
ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0007159
