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ArticlesPeer ReviewedFull Text
Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis
Author / Creator:Schumacher, Pia Philippa ; Ajendra, Jesuthas ; Lenz, Benjamin ; Risch, Frederic ; Ehrens, Alexandra ; Nieto-Pérez, Celia ; Koschel, Marianne ; Aden, Tilman ; Hoerauf, Achim ; Hübner, Marc P.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2025-03, Vol.19 (3), p.e0012889
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Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
Author / Creator:Lenz, Benjamin ; Ehrens, Alexandra ; Ajendra, Jesuthas ; Risch, Frederic ; Gal, Joséphine ; Neumann, Anna-Lena ; Reichwald, Julia J. ; Strutz, Wiebke ; McSorley, Henry J. ; Martin, Coralie ; Hoerauf, Achim ; Hübner, Marc P.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2024-03, Vol.20 (3), p.e1012071-e1012071
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Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro
Author / Creator:Hübner, Marc P. ; Martin, Coralie ; Specht, Sabine ; Koschel, Marianne ; Dubben, Bettina ; Frohberger, Stefan J. ; Ehrens, Alexandra ; Fendler, Martina ; Struever, Dominique ; Mitre, Edward ; Vallarino-Lhermitte, Nathaly ; Gokool, Suzanne ; Lustigman, Sara ; Schneider, Manfred ; Townson, Simon ; Hoerauf, Achim ; Scandale, Ivan
Publisher:San Francisco: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2020-07, Vol.14 (7), p.e0008427-e0008427
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Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
Author / Creator:Schiefer, Andrea ; Hübner, Marc P. ; Krome, Anna ; Lämmer, Christine ; Ehrens, Alexandra ; Aden, Tilman ; Koschel, Marianne ; Neufeld, Helene ; Chaverra-Muñoz, Lillibeth ; Jansen, Rolf ; Kehraus, Stefan ; König, Gabriele M. ; Pogorevc, Domen ; Müller, Rolf ; Stadler, Marc ; Hüttel, Stephan ; Hesterkamp, Thomas ; Wagner, Karl ; Pfarr, Kenneth ; Hoerauf, Achim
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2020-12, Vol.14 (12), p.e0008930-e0008930
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The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese indi...
Author / Creator:Lenz, Benjamin ; Andrew, Beng Amuam ; Ritter, Manuel ; Karunakaran, Indulekha ; Gandjui, Narcisse Victor Tchamatchoua ; Nchang, Lucy Cho ; Surendar, Jayagopi ; Ebob, Anita Obi Bate ; Ehrens, Alexandra ; Klarmann-Schulz, Ute ; Ricchiuto, Arcangelo ; Kuehlwein, Janina M. ; Fombad, Fanny Fri ; Ngwa, Ambe Marius ; Katcho, Tatiana Djikeussi ; Hoerauf, Achim ; Wanji, Samuel ; Hübner, Marc P.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2023-06, Vol.18 (6), p.e0285689-e0285689
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Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
Author / Creator:Frohberger, Stefan J. ; Ajendra, Jesuthas ; Surendar, Jayagopi ; Stamminger, Wiebke ; Ehrens, Alexandra ; Buerfent, Benedikt C. ; Gentil, Katrin ; Hoerauf, Achim ; Hübner, Marc P.
Publisher:England: BioMed Central Ltd
Journal title:Parasites & vectors, 2019-05, Vol.12 (1), p.248-248, Article 248
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S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis
Author / Creator:Frohberger, Stefan J. ; Fercoq, Frederic ; Neumann, Anna-Lena ; Surendar, Jayagopi ; Stamminger, Wiebke ; Ehrens, Alexandra ; Karunakaran, Indulekha ; Remion, Estelle ; Vogl, Thomas ; Hoerauf, Achim ; Martin, Coralie ; Hübner, Marc P.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2020-02, Vol.14 (2), p.e0008119-e0008119
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Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds
Author / Creator:Hübner, Marc P. ; Ehrens, Alexandra ; Koschel, Marianne ; Dubben, Bettina ; Lenz, Franziska ; Frohberger, Stefan J. ; Specht, Sabine ; Quirynen, Ludo ; Lachau-Durand, Sophie ; Tekle, Fetene ; Baeten, Benny ; Engelen, Marc ; Mackenzie, Charles D. ; Hoerauf, Achim
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2019-01, Vol.13 (1), p.e0006320
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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
Author / Creator:Hübner, Marc P. ; Koschel, Marianne ; Struever, Dominique ; Nikolov, Venelin ; Frohberger, Stefan J. ; Ehrens, Alexandra ; Fendler, Martina ; Johannes, Iliana ; von Geldern, Thomas W. ; Marsh, Kennan ; Turner, Joseph D. ; Taylor, Mark J. ; Ward, Stephen A. ; Pfarr, Kenneth ; Kempf, Dale J. ; Hoerauf, Achim
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2019-08, Vol.13 (8), p.e0007636-e0007636
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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
Author / Creator:von Geldern, Thomas W. ; Morton, Howard E. ; Clark, Rick F. ; Brown, Brian S. ; Johnston, Kelly L. ; Ford, Louise ; Specht, Sabine ; Carr, Robert A. ; Stolarik, Deanne F. ; Ma, Junli ; Rieser, Matthew J. ; Struever, Dominique ; Frohberger, Stefan J. ; Koschel, Marianne ; Ehrens, Alexandra ; Turner, Joseph D. ; Hübner, Marc P. ; Hoerauf, Achim ; Taylor, Mark J. ; Ward, Stephen A. ; Marsh, Kennan ; Kempf, Dale J.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2019-02, Vol.13 (2), p.e0007159
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ArticlesPeer ReviewedFull Text
Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations
Author / Creator:Becker, Tim ; Heitkötter, Jan ; Krome, Anna K. ; Schiefer, Andrea ; Pfarr, Kenneth ; Ehrens, Alexandra ; Grosse, Miriam ; Sandargo, Birthe ; Stammberger, Ingo ; Stadler, Marc ; Hübner, Marc P. ; Kehraus, Stefan ; Hoerauf, Achim ; Wagner, Karl G.
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2024-03, Vol.16 (3), p.386
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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis
Author / Creator:Ehrens, Alexandra ; Lunde, Christopher S. ; Jacobs, Robert T. ; Struever, Dominique ; Koschel, Marianne ; Frohberger, Stefan J. ; Lenz, Franziska ; Fendler, Martina ; Turner, Joseph D. ; Ward, Stephen A. ; Taylor, Mark J. ; Freund, Yvonne R. ; Stefanakis, Rianna ; Easom, Eric ; Li, Xianfeng ; Plattner, Jacob J. ; Hoerauf, Achim ; Hübner, Marc P.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2020-01, Vol.14 (1), p.e0007957-e0007957
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Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus
Author / Creator:Rox, Katharina ; Becker, Tim ; Schiefer, Andrea ; Grosse, Miriam ; Ehrens, Alexandra ; Jansen, Rolf ; Aden, Tilman ; Kehraus, Stefan ; König, Gabriele M. ; Krome, Anna K. ; Hübner, Marc P. ; Wagner, Karl G. ; Stadler, Marc ; Pfarr, Kenneth ; Hoerauf, Achim
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2022-12, Vol.15 (1), p.131
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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Author / Creator:Becker, Tim ; Krome, Anna K. ; Vahdati, Sahel ; Schiefer, Andrea ; Pfarr, Kenneth ; Ehrens, Alexandra ; Aden, Tilman ; Grosse, Miriam ; Jansen, Rolf ; Alt, Silke ; Hesterkamp, Thomas ; Stadler, Marc ; Hübner, Marc P. ; Kehraus, Stefan ; König, Gabriele M. ; Hoerauf, Achim ; Wagner, Karl G.
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2022-08, Vol.14 (8), p.1657
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AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Author / Creator:Hong, W. David ; Benayoud, Farid ; Nixon, Gemma L. ; Ford, Louise ; Johnston, Kelly L. ; Clare, Rachel H. ; Cassidy, Andrew ; Cook, Darren A. N. ; Siu, Amy ; Shiotani, Motohiro ; Webborn, Peter J. H. ; Kavanagh, Stefan ; Aljayyoussi, Ghaith ; Murphy, Emma ; Steven, Andrew ; Archer, John ; Struever, Dominique ; Frohberger, Stefan J. ; Ehrens, Alexandra ; Hübner, Marc P. ; Hoerauf, Achim ; Roberts, Adam P. ; Hubbard, Alasdair T. M. ; Tate, Edward W. ; Serwa, Remigiusz A. ; Leung, Suet C. ; Qie, Li ; Berry, Neil G. ; Gusovsky, Fabian ; Hemingway, Janet ; Turner, Joseph D. ; Taylor, Mark J. ; Ward, Stephen A. ; O’Neill, Paul M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (4), p.1414-1419
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Apparent activation energies of protein–protein complex dissociation in the gas–phase determined by electrospray mass spectrometry
Author / Creator:Yefremova, Yelena ; Melder, F. Teresa I. ; Danquah, Bright D. ; Opuni, Kwabena F.M. ; Koy, Cornelia ; Ehrens, Alexandra ; Frommholz, David ; Illges, Harald ; Koelbel, Knut ; Sobott, Frank ; Glocker, Michael O.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2017-11, Vol.409 (28), p.6549-6558
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Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis

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Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner

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Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

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Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

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The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese indi...

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Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

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S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

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Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

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Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations

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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

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Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus

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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

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AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

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Apparent activation energies of protein–protein complex dissociation in the gas–phase determined by electrospray mass spectrometry

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