Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory...
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that expression of granulin peptides, the cleavage produc...
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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response
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TN_cdi_plos_journals_2291478182
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2291478182
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1008295
