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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory...

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2291478182

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

About this item

Full title

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2019-08, Vol.15 (8), p.e1008295-e1008295

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that expression of granulin peptides, the cleavage produc...

Alternative Titles

Full title

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2291478182

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2291478182

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1008295

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