After publication of this article [1], several concerns were raised for Figs 3, 4 and 6: * In Fig 3A, there appears to be overlap between the following image pairs, suggesting that all four of the affected panels may represent data from the same slide: * DR4 TRAIL panel (row 1, column 3) and DR5 Resveratrol panel (row 2, column 2) * DR5 Resveratrol panel and DR5 TRAIL panel (row 2, column 3) * DR4 Resveratrol panel (row 1, column 2) and DR5 TRAIL panel The authors provide here an updated version of Fig 3A in which they replaced all panels for the DR4 and DR5 immunohistochemistry experiments. thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Fig 3. Proteins extracts were prepared and the expressions of DRs were measured as per manufacturer's instructions. https://doi.org/10.1371/journal.pone.0223138.g001 * In Fig 4A, regions of overlap were noted between the Bax/Resveratrol, Bax/TRAIL, and Bax/Resveratrol+TRAIL immunohistochemistry panels (row 1, columns 1–3) suggesting that these images were derived from the same original slide. Right panel, tumor sections from control and drug-treated mice obtained on week 6 were stained with anti-von Willeb...

Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor

10.1371/journal.pone.0223138