Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity. For example, adverse drug reactions when patients receive CPT-11 (irinotecan) such as in cancer chemotherapy are caused...
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Full title
Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
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TN_cdi_plos_journals_2314766339
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2314766339
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0225244
