Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug depl...
Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
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Author / Creator
Chevalier, Frédéric D , Le Clec'h, Winka , McDew-White, Marina , Menon, Vinay , Guzman, Meghan A , Holloway, Stephen P , Cao, Xiaohang , Taylor, Alexander B , Kinung'hi, Safari , Gouvras, Anouk N , Webster, Bonnie L , Webster, Joanne P , Emery, Aidan M , Rollinson, David , Garba Djirmay, Amadou , Al Mashikhi, Khalid M , Al Yafae, Salem , Idris, Mohamed A , Moné, Hélène , Mouahid, Gabriel , Hart, P John , LoVerde, Philip T and Anderson, Timothy J C
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that alleles conferring resistance to oxamniquine (OXA), an...
Alternative Titles
Full title
Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Authors, Artists and Contributors
Author / Creator
Le Clec'h, Winka
McDew-White, Marina
Menon, Vinay
Guzman, Meghan A
Holloway, Stephen P
Cao, Xiaohang
Taylor, Alexander B
Kinung'hi, Safari
Gouvras, Anouk N
Webster, Bonnie L
Webster, Joanne P
Emery, Aidan M
Rollinson, David
Garba Djirmay, Amadou
Al Mashikhi, Khalid M
Al Yafae, Salem
Idris, Mohamed A
Moné, Hélène
Mouahid, Gabriel
Hart, P John
LoVerde, Philip T
Anderson, Timothy J C
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2314933855
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2314933855
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1007881
