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SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-sp...

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-sp...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2355998112

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces

About this item

Full title

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces

Publisher

United States: Public Library of Science

Journal title

PLoS biology, 2020-01, Vol.18 (1), p.e3000596-e3000596

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of absent excitability modulation. Mice with a Purkinje-cell-s...

Alternative Titles

Full title

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2355998112

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2355998112

Other Identifiers

ISSN

1545-7885,1544-9173

E-ISSN

1545-7885

DOI

10.1371/journal.pbio.3000596

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