3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial ce...
3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and inflammation. In addition to modulating endothelial proliferation and migration, 3PO also dampens proinflammatory activation of...
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Full title
3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3
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TN_cdi_plos_journals_2371506896
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2371506896
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0229395
