NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the detailed molecular mechanisms by...
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Full title
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
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TN_cdi_plos_journals_2377705340
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2377705340
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3000620
