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Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modular...

Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modular...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2414405326

Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso

About this item

Full title

Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso

Publisher

United States: Public Library of Science

Journal title

PloS one, 2020-06, Vol.15 (6), p.e0234748-e0234748

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Large-scale genome wide association studies (GWASs) have led to discovery of many genetic risk factors in Alzheimer's disease (AD), such as APOE, TOMM40 and CLU. Despite the significant progress, it remains a major challenge to functionally validate these genetic findings and translate them into targetable mechanisms. Integration of multiple types...

Alternative Titles

Full title

Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2414405326

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2414405326

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0234748

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