Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using...
Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry
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Author / Creator
Wang, Chao , Zhang, Jingui , Zhou, Simin , Yu, Limei , Han, Fangxuan , Ling, Ren and Ling, Jin
Publisher
San Francisco: Public Library of Science
Journal title
Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Background Gefitinib is an orally potent and selective ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase and is commonly used to treat locally advanced or metastatic non-small-cell lung cancer (NSCLC) with sensitive EGFR mutations. Multiple adverse effects associated with gefitinib, including liver and lung injuri...
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Full title
Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry
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Record Identifier
TN_cdi_plos_journals_2426534094
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2426534094
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0236523
