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Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinica...

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinica...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2430656555

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats

About this item

Full title

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats

Publisher

San Francisco: Public Library of Science

Journal title

PloS one, 2020-08, Vol.15 (8), p.e0236754-e0236754

Language

English

Formats

Publication information

Publisher

San Francisco: Public Library of Science

More information

Scope and Contents

Contents

The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections. A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. The assay's lower limit of quantification was 250 ng/mL. The mean ± standa...

Alternative Titles

Full title

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2430656555

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2430656555

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0236754

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