Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Scope and Contents
Contents
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill a signaling function, the virus needs to activate downstream factors to trigger endocytic upta...
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Full title
Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
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TN_cdi_plos_journals_2434497642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2434497642
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008656
