HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling
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Author / Creator
Loh, Zhixuan , Simpson, Jennifer , Ullah, Ashik , Zhang, Vivian , Gan, Wan J , Lynch, Jason P , Werder, Rhiannon B , Sikder, Al Amin , Lane, Katie , Sim, Choon Boon , Porrello, Enzo , Mazzone, Stuart B , Sly, Peter D , Steptoe, Raymond J , Spann, Kirsten M , Sukkar, Maria B , Upham, John W , Phipps, Simon and Heise, Mark T
Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Scope and Contents
Contents
Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe respiratory viral infections in infancy predispose to later asthma, however, the processes that mediate tissue damage-induced type-2 inflammation and the origins of airway remodelling remain i...
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Full title
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling
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TN_cdi_plos_journals_2434497646
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2434497646
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008651
