An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
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Author / Creator
Kobylarz, Marek J , Goodwin, Jonathan M , Kang, Zhao B , Annand, John W , Hevi, Sarah , O'Mahony, Ellen , McAllister, Gregory , Reece-Hoyes, John , Wang, Qiong , Alford, John , Russ, Carsten , Lindeman, Alicia , Beibel, Martin , Roma, Guglielmo , Carbone, Walter , Knehr, Judith , Loureiro, Joseph , Antczak, Christophe , Wiederschain, Dmitri , Murphy, Leon O , Menon, Suchithra and Nyfeler, Beat
Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell growth, we performed unbiased cell line profiling studies with the selective VPS34 inhibitor PIK-III and identified RKO as a VPS34-dependent cellular model. Pooled CRISPR scre...
Alternative Titles
Full title
An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
Authors, Artists and Contributors
Author / Creator
Goodwin, Jonathan M
Kang, Zhao B
Annand, John W
Hevi, Sarah
O'Mahony, Ellen
McAllister, Gregory
Reece-Hoyes, John
Wang, Qiong
Alford, John
Russ, Carsten
Lindeman, Alicia
Beibel, Martin
Roma, Guglielmo
Carbone, Walter
Knehr, Judith
Loureiro, Joseph
Antczak, Christophe
Wiederschain, Dmitri
Murphy, Leon O
Menon, Suchithra
Nyfeler, Beat
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Record Identifier
TN_cdi_plos_journals_2436840873
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2436840873
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0235551
