Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology...
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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High levels of the amyloid-beta (Aβ) peptide have been shown to disrupt neuronal function and induce hyperexcitability, but it is unclear what effects Aβ-associated hyperexcitability may have on tauopathy pathogenesis or propagation in vivo. Using a novel transgenic mouse line to model the impact of human APP (hAPP)/Aβ accumulation on tauopathy in...
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Full title
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus
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TN_cdi_plos_journals_2443588564
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2443588564
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3000851
