Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cel...
Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data
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Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological information. In this work, we approach this problem b...
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Full title
Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data
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TN_cdi_plos_journals_2451547380
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2451547380
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1008173
