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Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathway...

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathway...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2460786215

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

About this item

Full title

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

Publisher

United States: Public Library of Science

Journal title

PLoS medicine, 2020-01, Vol.17 (1), p.e1003012-e1003012

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is critical to identifying novel targets for disease-modifying therapies. In this study, we test whether AD pathogene...

Alternative Titles

Full title

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2460786215

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2460786215

Other Identifiers

ISSN

1549-1676,1549-1277

E-ISSN

1549-1676

DOI

10.1371/journal.pmed.1003012

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