Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs). In mice, HPK1 deficiency subverts inhibition of the anti-tumor immune response and is associated with functional augment...
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Full title
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
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TN_cdi_plos_journals_2466766963
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2466766963
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0243145
