Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate...
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a basic model, using detailed linkage disequilibrium...
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Full title
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
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TN_cdi_plos_journals_2479457848
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2479457848
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1008612
