Impact of variant-level batch effects on identification of genetic risk factors in large sequencing...
Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies
About this item
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Author / Creator
Wickland, Daniel P , Ren, Yingxue , Sinnwell, Jason P , Reddy, Joseph S , Pottier, Cyril , Sarangi, Vivekananda , Carrasquillo, Minerva M , Ross, Owen A , Younkin, Steven G , Ertekin-Taner, Nilüfer , Rademakers, Rosa , Hudson, Matthew E , Mainzer, Liudmila Sergeevna , Biernacka, Joanna M and Asmann, Yan W
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide Association Studies using Single Nucleotide Polymorphism chips. Sequencing-based studies require large sample sizes for statistical power and therefore often inadvertently introduce batch effects be...
Alternative Titles
Full title
Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies
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Record Identifier
TN_cdi_plos_journals_2513668159
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2513668159
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0249305
