Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets rep...
Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Scope and Contents
Contents
DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene activation significantly alters DNA replication dynamics, causing replication stress and genome instabi...
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Full title
Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion
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TN_cdi_plos_journals_2523091034
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2523091034
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0251188
