Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop fo...
Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients with preexisting autoimmunity. However, to date, the molecular and cellular profiles of such comorbidities are poorly understood. We used Aicardi-Goutières syndrome (AGS...
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Full title
Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions
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TN_cdi_plos_journals_2528224823
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2528224823
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009523
