The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK...
The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling. Our results showed that S100B affects IL6 expression transcriptionally. S100B was shown to form a c...
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Full title
The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling
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TN_cdi_plos_journals_2562821730
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2562821730
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0256238
