Unbiased high-content screening reveals Aβ- and tau-independent synaptotoxic activities in human bra...
Unbiased high-content screening reveals Aβ- and tau-independent synaptotoxic activities in human brain homogenates from Alzheimer's patients and high-pathology controls
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Alzheimer's disease (AD) is tightly correlated with synapse loss in vulnerable brain regions. It is assumed that specific molecular entities such as Aβ and tau cause synapse loss in AD, yet unbiased screens for synaptotoxic activities have not been performed. Here, we performed size exclusion chromatography on soluble human brain homogenates from A...
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Full title
Unbiased high-content screening reveals Aβ- and tau-independent synaptotoxic activities in human brain homogenates from Alzheimer's patients and high-pathology controls
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TN_cdi_plos_journals_2595082457
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2595082457
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0259335
