Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal...
Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR
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United States: Public Library of Science
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English
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United States: Public Library of Science
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ERBB3 has gained attention as a potential therapeutic target to treat colorectal and other types of cancers. To confirm a previous study showing intestinal polyps are dependent upon ERBB3, we generated an intestinal epithelia-specific ERBB3 deletion in C57BL/6-ApcMin/+ mice. Contrary to the previous report showing a significant reduction in intesti...
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Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR
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TN_cdi_plos_journals_2610941934
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2610941934
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009931
