Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochond...
Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SETD8 and NSD2 inhibited the senescence program in cultured fibroblasts. Here, we report that loss of...
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Full title
Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation
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TN_cdi_plos_journals_2623344160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2623344160
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0262488
