The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
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United States: Public Library of Science
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English
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United States: Public Library of Science
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ABCA1 and ABCA4 are enigmatic because they transport substrates in opposite directions yet share >50% amino acid identity. ABCA4 imports lipid conjugates but ABCA1 exports lipids. Both hydrolyze ATP to drive transport, and both contain cytoplasmic regulatory domains (RDs) following nucleotide-binding domains (NBDs) in the primary structure. The ter...
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Full title
The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
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TN_cdi_plos_journals_2625529027
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2625529027
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0262746
