Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian ran...
Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on the basis that they primarily modify low-density lipoprotein (LDL) cholesterol (HMGCR, PCKS9, and NPC...
Alternative Titles
Full title
Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2640116742
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2640116742
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001547
