Identification of cell type specific ACE2 modifiers by CRISPR screening
Identification of cell type specific ACE2 modifiers by CRISPR screening
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both
in vivo
and in immortalized cell lines, but the molecular pathways that govern ACE2 expression remain unclear. We now report high-throughput CRISPR screens for functional modifiers...
Alternative Titles
Full title
Identification of cell type specific ACE2 modifiers by CRISPR screening
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TN_cdi_plos_journals_2651150448
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2651150448
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010377
