Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as k...
Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Comparing SARS-CoV-2 infection-induced gene expression signatures to drug treatment-induced gene expression signatures is a promising bioinformatic tool to repurpose existing drugs against SARS-CoV-2. The general hypothesis of signature-based drug repurposing is that drugs with inverse similarity to a disease signature can reverse disease phenotype...
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Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity
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TN_cdi_plos_journals_2665140023
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2665140023
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1010021
