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Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperativ...

Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperativ...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2686848862

Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

About this item

Full title

Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

Publisher

San Francisco: Public Library of Science

Journal title

PloS one, 2022-07, Vol.17 (7), p.e0271119-e0271119

Language

English

Formats

Publication information

Publisher

San Francisco: Public Library of Science

More information

Scope and Contents

Contents

Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its proper metabolism, which can be triggered by epigenetic modifications. Consequently, we tested th...

Alternative Titles

Full title

Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2686848862

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2686848862

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0271119

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