Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) ad...
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer
About this item
Full title
Author / Creator
Shoemaker, Robert H. , Panettieri, Reynold A. , Libutti, Steven K. , Hochster, Howard S. , Watts, Norman R. , Wingfield, Paul T. , Starkl, Philipp , Pimenov, Lisabeth , Gawish, Riem , Hladik, Anastasiya , Knapp, Sylvia , Boring, Daniel , White, Jonathan M. , Lawrence, Quentin , Boone, Jeremy , Marshall, Jason D. , Matthews, Rebecca L. , Cholewa, Brian D. , Richig, Jeffrey W. , Chen, Ben T. , McCormick, David L. , Gugensberger, Romana , Höller, Sonja , Penninger, Josef M. and Wirnsberger, Gerald
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung damage caused by deregulated signaling in the renin-angiotensin (RAS) and Kinin pathways. Here, after de...
Alternative Titles
Full title
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer
Authors, Artists and Contributors
Author / Creator
Panettieri, Reynold A.
Libutti, Steven K.
Hochster, Howard S.
Watts, Norman R.
Wingfield, Paul T.
Starkl, Philipp
Pimenov, Lisabeth
Gawish, Riem
Hladik, Anastasiya
Knapp, Sylvia
Boring, Daniel
White, Jonathan M.
Lawrence, Quentin
Boone, Jeremy
Marshall, Jason D.
Matthews, Rebecca L.
Cholewa, Brian D.
Richig, Jeffrey W.
Chen, Ben T.
McCormick, David L.
Gugensberger, Romana
Höller, Sonja
Penninger, Josef M.
Wirnsberger, Gerald
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2688057447
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2688057447
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0271066
