OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation wit...
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
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San Francisco: Public Library of Science
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Language
English
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San Francisco: Public Library of Science
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Contents
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy. Orexins act on two receptor subtypes, OX1R and OX2R, the latter being more strongly implicated in sleep/wake regu...
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Full title
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
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TN_cdi_plos_journals_2693033755
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2693033755
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0271901
