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Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments i...

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments i...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2703164485

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis

About this item

Full title

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2022-07, Vol.18 (7), p.e1010705

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Despite the existence of well-characterized, canonical mutations that confer high-level drug resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance mechanisms are more complex than simple acquisition of such mutations. Recent studies have shown that Mtb can acquire non-canonical resistance-associated mutations that c...

Alternative Titles

Full title

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2703164485

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2703164485

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1010705

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