SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain i...
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
About this item
Full title
Author / Creator
Niemeyer, Daniela , Stenzel, Saskia , Veith, Talitha , Schroeder, Simon , Friedmann, Kirstin , Weege, Friderike , Trimpert, Jakob , Heinze, Julian , Richter, Anja , Jansen, Jenny , Emanuel, Jackson , Kazmierski, Julia , Pott, Fabian , Jeworowski, Lara M. , Olmer, Ruth , Jaboreck, Mark-Christian , Tenner, Beate , Papies, Jan , Walper, Felix , Schmidt, Marie L. , Heinemann, Nicolas , Möncke-Buchner, Elisabeth , Baumgardt, Morris , Hoffmann, Karen , Widera, Marek , Thao, Tran Thi Nhu , Balázs, Anita , Schulze, Jessica , Mache, Christin , Jones, Terry C. , Morkel, Markus , Ciesek, Sandra , Hanitsch, Leif G. , Mall, Marcus A. , Hocke, Andreas C. , Thiel, Volker , Osterrieder, Klaus , Wolff, Thorsten , Martin, Ulrich , Corman, Victor M. , Müller, Marcel A. , Goffinet, Christine and Drosten, Christian
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC remain understudied. Here, we provide an extensive functional study of VOC Alpha replication and cell en...
Alternative Titles
Full title
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
Authors, Artists and Contributors
Author / Creator
Stenzel, Saskia
Veith, Talitha
Schroeder, Simon
Friedmann, Kirstin
Weege, Friderike
Trimpert, Jakob
Heinze, Julian
Richter, Anja
Jansen, Jenny
Emanuel, Jackson
Kazmierski, Julia
Pott, Fabian
Jeworowski, Lara M.
Olmer, Ruth
Jaboreck, Mark-Christian
Tenner, Beate
Papies, Jan
Walper, Felix
Schmidt, Marie L.
Heinemann, Nicolas
Möncke-Buchner, Elisabeth
Baumgardt, Morris
Hoffmann, Karen
Widera, Marek
Thao, Tran Thi Nhu
Balázs, Anita
Schulze, Jessica
Mache, Christin
Jones, Terry C.
Morkel, Markus
Ciesek, Sandra
Hanitsch, Leif G.
Mall, Marcus A.
Hocke, Andreas C.
Thiel, Volker
Osterrieder, Klaus
Wolff, Thorsten
Martin, Ulrich
Corman, Victor M.
Müller, Marcel A.
Goffinet, Christine
Drosten, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2755148946
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2755148946
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001871
