A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the packaging of guideRNA-encoding lentiviral vector genomes into the supernatant of budding virions as...
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Full title
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
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TN_cdi_plos_journals_2777449530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2777449530
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011101
