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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2777449530

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

About this item

Full title

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2023-01, Vol.19 (1), p.e1011101

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the packaging of guideRNA-encoding lentiviral vector genomes into the supernatant of budding virions as...

Alternative Titles

Full title

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2777449530

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2777449530

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1011101

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