A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Ca...
A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development
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United States: Public Library of Science
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English
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United States: Public Library of Science
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In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism of D-2HG remains unclear in any organism. Here, we find that, in Caenorhabditis elegans, D-2HG i...
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A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development
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TN_cdi_plos_journals_2814430353
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2814430353
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3002057
