SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database minin...
SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
An effective approach to reverse multidrug resistance (MDR) is P-glycoprotein (P-gp, ABCB1) transport inhibition. To identify such molecular regulators, the SuperNatural II database, which comprises > 326,000 compounds, was virtually screened for ABCB1 transporter inhibitors. The Lipinski rule was utilized to initially screen the SuperNatural II da...
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Full title
SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study
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TN_cdi_plos_journals_2842433457
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2842433457
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0288919
