The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza viru...
The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice
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Author / Creator
Yang, Hui , Dong, Yurui , Bian, Ying , Huo, Chenzhi , Zhu, Chuncheng , Qin, Tao , Chen, Sujuan , Peng, Daxin and Liu, Xiufan
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The avian influenza virus (AIV) PA protein contributes to viral replication and pathogenicity; however, its interaction with innate immunity is not well understood. Here, we report that the H5 subtype AIV PA protein strongly suppresses host antiviral defense by interacting with and degrading a key protein in interferon (IFN) signaling, Janus kinase...
Alternative Titles
Full title
The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice
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Record Identifier
TN_cdi_plos_journals_2851955491
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2851955491
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011489
