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Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potent...

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potent...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2854906689

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

About this item

Full title

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

Publisher

San Francisco: Public Library of Science

Journal title

PloS one, 2023-08, Vol.18 (8), p.e0277718-e0277718

Language

English

Formats

Publication information

Publisher

San Francisco: Public Library of Science

More information

Scope and Contents

Contents

Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of serum concentration and clearance, is formulated as an oral drug in a patient population plagued with dysphagia, and has k...

Alternative Titles

Full title

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2854906689

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2854906689

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0277718

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