Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated anti...
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
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Author / Creator
Mhlekude, Baxolele , Postmus, Dylan , Stenzel, Saskia , Weiner, January , Jansen, Jenny , Zapatero-Belinchón, Francisco J. , Olmer, Ruth , Richter, Anja , Heinze, Julian , Heinemann, Nicolas , Mühlemann, Barbara , Schroeder, Simon , Jones, Terry C. , Müller, Marcel A. , Drosten, Christian , Pich, Andreas , Thiel, Volker , Martin, Ulrich , Niemeyer, Daniela , Gerold, Gisa , Beule, Dieter and Goffinet, Christine
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibility to viral subversion remain incompletely understood. Pretreatment of cells with iBETs inhibited in...
Alternative Titles
Full title
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Authors, Artists and Contributors
Author / Creator
Postmus, Dylan
Stenzel, Saskia
Weiner, January
Jansen, Jenny
Zapatero-Belinchón, Francisco J.
Olmer, Ruth
Richter, Anja
Heinze, Julian
Heinemann, Nicolas
Mühlemann, Barbara
Schroeder, Simon
Jones, Terry C.
Müller, Marcel A.
Drosten, Christian
Pich, Andreas
Thiel, Volker
Martin, Ulrich
Niemeyer, Daniela
Gerold, Gisa
Beule, Dieter
Goffinet, Christine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_3069180346
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3069180346
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011657
