Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycoca...
Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx
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Author / Creator
Schaaf, Kaitlyn R , Landstreet, Stuart R , Putz, Nathan D , Gonski, Samantha K , Lin, Jason , Buggs, Charity J , Gibson, Dustin , Langouët-Astrié, Christophe J , Jetter, Christopher S , Negretti, Nicolas M , Sucre, Jennifer M S , Schmidt, Eric P , Ware, Lorraine B , Bastarache, Julie A and Shaver, Ciara M
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The alveolar epithelium is protected by a heparan sulfate-rich, glycosaminoglycan layer called the epithelial glycocalyx. It is cleaved in patients with acute respiratory distress syndrome (ARDS) and in murine models of influenza A (IAV) infection, shedding fragments into the airspace from the cell surface. Glycocalyx shedding results in increased...
Alternative Titles
Full title
Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx
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Record Identifier
TN_cdi_plos_journals_3108572558
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3108572558
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0308648
