Computational investigation of missense somatic mutations in cancer and potential links to pH-depend...
Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Metabolic changes during tumour development lead to acidification of the extracellular environment and a smaller increase of intracellular pH. Searches for somatic missense mutations that could reveal adaptation to altered pH have focussed on arginine to histidine changes, part of a general arginine depletion that originates from DNA mutational mec...
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Full title
Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasis
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TN_cdi_plos_journals_3130599307
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3130599307
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0314022
