Optogenetic screening of MCT1 activity implicates a cluster of non-steroidal anti-inflammatory drugs...
Optogenetic screening of MCT1 activity implicates a cluster of non-steroidal anti-inflammatory drugs (NSAIDs) as inhibitors of lactate transport
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Lactate transport plays a crucial role in the metabolism, microenvironment, and survival of cancer cells. However, current drugs targeting either MCT1 or MCT4, which traditionally mediate lactate import or efflux respectively, show limited efficacy beyond in vitro models. This limitation partly arises from the existence of both isoforms in certain...
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Optogenetic screening of MCT1 activity implicates a cluster of non-steroidal anti-inflammatory drugs (NSAIDs) as inhibitors of lactate transport
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TN_cdi_plos_journals_3143786185
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3143786185
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0312492
