Spherical Aggregates of β-Amyloid (Amylospheroid) Show High Neurotoxicity and Activate Tau Protein K...
Spherical Aggregates of β-Amyloid (Amylospheroid) Show High Neurotoxicity and Activate Tau Protein Kinase I/Glycogen Synthase Kinase-3β
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
$\beta\!-\!Amyloid\>(A\beta)$acquires toxicity by self-aggregation. To identify and characterize the toxic form(s) of Aβ aggregates, we examined in vitro aggregation conditions by using large quantities of homogenous, chemically synthesized Aβ1-40peptide. We found that slow rotation of Aβ1-40solution reproducibly gave self-aggregated Aβ1-40containi...
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Full title
Spherical Aggregates of β-Amyloid (Amylospheroid) Show High Neurotoxicity and Activate Tau Protein Kinase I/Glycogen Synthase Kinase-3β
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TN_cdi_pnas_primary_100_11_6370_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_11_6370_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1237107100
