The Kinase Inhibitor Imatinib Mesylate Inhibits TNF-α Production in vitro and Prevents TNF-Dependent...
The Kinase Inhibitor Imatinib Mesylate Inhibits TNF-α Production in vitro and Prevents TNF-Dependent Acute Hepatic Inflammation
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Publisher
Washington: National Academy of Sciences
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Language
English
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Publisher
Washington: National Academy of Sciences
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Contents
Imatinib exerts potent antileukemic effects in vitro and in vivo. Despite its well known antitumor activity, the potential of imatinib for the treatment of inflammatory diseases remains elusive so far. Our current report provides strong evidence that imatinib has potent antiinflammatory effects. It potently inhibits LPS- and Con A-induced TNF-α pro...
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Full title
The Kinase Inhibitor Imatinib Mesylate Inhibits TNF-α Production in vitro and Prevents TNF-Dependent Acute Hepatic Inflammation
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TN_cdi_pnas_primary_102_38_13622
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_38_13622
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0501758102
