Aberrant Wnt/β-Catenin Signaling Can Induce Chromosomal Instability in Colon Cancer
Aberrant Wnt/β-Catenin Signaling Can Induce Chromosomal Instability in Colon Cancer
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Chromosomal instability (CIN), a hallmark of most colon tumors, may promote tumor progression by increasing the rate of genetic aberrations. CIN is thought to arise as a consequence of improper mitosis and spindle checkpoint activity, but its molecular basis remains largely elusive. The majority of colon tumors develop because of mutations in the t...
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Full title
Aberrant Wnt/β-Catenin Signaling Can Induce Chromosomal Instability in Colon Cancer
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TN_cdi_pnas_primary_103_28_10747
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_103_28_10747
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0604206103
